The gene mutation responsible for the wrinkled skin of Shar-Pei dogs is also linked to a periodic fever disorder, a finding that could have important implications for human health, researchers report. Shar-Pei dogs have a high prevalence of a periodic fever disorder that is similar to inherited autoinflammatory periodic fever syndromes in humans. The thick, wrinkled skin of Shar-Pei dogs contains an excess of hyaluronan, most likely because of an over-activation of the hyaluronan synthase 2 (HAS2) gene. The fever disorder in the dogs occurs when overproduction of hyaluronan activates the immune system, according to scientists at the Broad Institute in Cambridge, Mass., and Uppsala University in Sweden. Read more . . .